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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Clinical and experimental use of ketamine in psychiatry
 Rydzyková, Tereza ; Tylš, Filip (advisor) ; Melkes, Barbora (referee)
Ketamine (NMDA receptor antagonist) is used primarily as an anesthetic in medicine. This paper deals with the use of ketamine in psychiatric research. A brief section approaching pharmacology and neurobiological effects of this substance, is followed by the main essay dealing within the first part with the use of ketamine as a potential new antidepressant drug. Preclinical and clinical studies demonstrating the effectiveness of this substance are described. Than neurobiological mechanisms underlying antidepressant action of ketamine are discussed. The second part of this review focuses on the use of ketamine as a pharmacological model of psychosis. Also published animal studies and studies administering ketamine in healthy subjects and schizophrenic patients are outlined. Subsequently neurobiological mechanism by which ketamine induces a psychotic state is proposed. Key words: Ketamine, NMDA receptor, schizophrenia, treatment-resistant depression, model of psychosis, antidepressant drug
Detailed record
Clinical and experimental use of ketamine in psychiatry
 Rydzyková, Tereza ; Tylš, Filip (advisor) ; Melkes, Barbora (referee)
Ketamine (NMDA receptor antagonist) is used primarily as an anesthetic in medicine. This paper deals with the use of ketamine in psychiatric research. A brief section approaching pharmacology and neurobiological effects of this substance, is followed by the main essay dealing within the first part with the use of ketamine as a potential new antidepressant drug. Preclinical and clinical studies demonstrating the effectiveness of this substance are described. Than neurobiological mechanisms underlying antidepressant action of ketamine are discussed. The second part of this review focuses on the use of ketamine as a pharmacological model of psychosis. Also published animal studies and studies administering ketamine in healthy subjects and schizophrenic patients are outlined. Subsequently neurobiological mechanism by which ketamine induces a psychotic state is proposed. Key words: Ketamine, NMDA receptor, schizophrenia, treatment-resistant depression, model of psychosis, antidepressant drug
Detailed record

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